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For translation, multi-parameter panels that combine CSF/serum lipid-peroxidation markers (e.g., F 2 -isoprostanes, HNE adducts), protein injury footprints (nitrotyrosine, carbonyls) and compartment-targeted reporters in experimental models (matrix/ER/nuclear H 2 O 2 sensors, peroxiredoxin redox state) and that are aligned to cognitive or motor end-points allow mechanism-anchored evaluation of interventions (Murphy et al